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SCHEDULEDay 3Thursday, March 57:30 AM - 8:00 AMREGISTRATION8:00 AM - 8:10 AMOPENING REMARKSLinda Brubaker, MD, MS ProfessorUniversity of California San Diego8:10 AM - 8:35 AMBeyond Sequencing: Community CharacteristicsRob Knight, PhD Professor & DirectorCenter for Microbiome Innovation UC San Diego8:35 AM - 9:00 AMBeyond Sequencing: 3D MappingPieter Dorrestein, PhD DirectorCollaborative Mass Spectrometry Innovation Center UC San Diego9:00 AM - 9:50 AMLABORATORY SCIENCE PANELMC: Alan Wolfe, PhDBenchmarking Studies for Specimen Collection, Storage, & Analysis:David Pride, MD, PhDBacteriophages in the Urobiome: Catherine Putonti, PhDMicrobial Interactions: Amanda Lewis, PhD9:50 AM - 10:10 AMQ&A10:10 AM - 10:30 AMBREAK10:30 AM - 11:20 AM CLINICAL SCIENCE PANELMC: Emily Lukacz, MDUrothelial Cells in Clinical Practice: James Malone-Lee, PhDUTI: Linda Brubaker, MD, MSUrinary Incontinence & Overactive Bladder: Nazema Siddiqui, MD, MHSKidney Stones: Andrew Schwaderer, MDPediatric Urology: Douglas Storm, MD11:20 AM - 11:40 AMQ&A

SCHEDULE11:40 AM - 11:50 AMForming Consensus to Advance Urobiome ResearchLinda Brubaker, MD, MS ProfessorUniversity of California San Diego11:50 AM - 1:15 PMWORKING LUNCHConcurrent Consensus Groups:Specimen Collection & Storage:David Pride, MD, PhD & Alan Wolfe, PhDCore Metadata & Urobiome Study Design:Emily Lukacz, MD & Nazema Siddiqui, MD, MHSBioinformatic Approaches:Qunfeng Dong, PhD & Lisa Karstens, PhD1:15 PM - 2:45 PMGROUP REPORTS, DISCUSSION, &DISSEMINATION PLANNING2:45 PM - 3:00 PMBREAK3:00 PM - 3:30 PMScience BlitzJunior Investigators3:30 PM - 4:00 PMBeyond BacteriaLenore Ackerman, MD, PhD Assistant ProfessorCedars-Sinai Medical Center4:00 PM - 4:30 PMModulating Microbiomes: Phage TherapyRobert Schooley, MD Professor of MedicineUniversity of California San Diego4:30 PM - 5:30 PMSOCIAL HOUR & NETWORKING

2020ORGANIZER &SPEAKER INFORMATION

ORGANIZERSRob Knight, PhDFaculty DirectorCenter for Microbiome Innovation at University of California San DiegoRob Knight is the Director of the Center for Microbiome Innovation at UC San Diego, wherehe is a Professor of Pediatrics, Bioengineering, and Computer Science & Engineering. Heco-founded the Earth Microbiome Project, and the American GutProject, which is among the largest crowdfunded scienceprojects of any kind to date. He has spoken at TED andwritten three books and over 600 scientific articles. Hewas honored with the 2019 NIH Director’s Pioneer Awardfor his microbiome research and won the 2017 MassryPrize, often considered a predictor of the Nobel. Hiswork combines microbiology, DNA sequencing, ecologyand computer science to understand the vast numbers ofmicrobes that inhabit our bodies and our planet.Sandrine Miller-Montgomery, PharmD, PhDExecutive DirectorCenter for Microbiome Innovation at University of California San DiegoDr. Sandrine Miller-Montgomery is co-leading the UC San Diego Center for MicrobiomeInnovation as executive director with Pr. Rob Knight. In this position, she is leading ateam focused on fostering and expanding collaborations with both industry and academicpartners. The mission of the CMI is to accelerate Microbiome discovery while creatinginnovative technologies that will support this emerging but exploding field in the consumerworld, while also enabling major clinical breakthroughs. She is building the success of thecenter with a leadership team of scientific experts along with herown business expertise from her years in industry.She comes directly from industry and has worked in largebiotech and multinational companies as well as startups. Most recently, she was CEO of MO BIO Laboratories,a biotech company focused on nucleic acidpurification solutions.Sandrine received both her PharmD and her PhD in LifeScience from the University of Bordeaux (France), withemphasis on molecular biology, biology of aging and thrombosis,and hemostasis.

GUEST MCMARGARET MCFALL-NGAI, PhDDirector of Pacific Biosciences Research CenterUniversity of Hawaii at ManoaDr. Margaret McFall-Ngai is Professor and Director of thePacific Biosciences Research Center at the Universityof Hawaii-Manoa. She has instituted the Center forMicrobiome Analysis through Island Knowledge andInvestigation (C-MAIKI ) at UH-M, and is PI of the WM KeckFoundation’s environmental microbiome observatory anda Gordon and Betty Moore Foundation grant for the studyof aquatic symbioses. McFall-Ngai is a pioneer in animalbacteria symbiosis and microbiome studies, using bobtailsquid as a model organism. She is a member of the AmericanAcademy of Microbiology (2002), the American Academy of Artsand Sciences (2011), and the National Academy of Sciences (2014). Sheis also a Howard Hughes Medical Institute Professor (2018-), and an ARCS FoundationScientist of the Year.McFall-Ngai’s research has combined training experiences in both organismal andmolecular biology to develop two major focuses: host-bacterial symbiosis; and the‘design’ of tissues that interact with light. The experimental strategy for both areas ofresearch relies on methods that have been developed for the study of the squid-vibrioassociation over the past 30 years. In addition, she has a continuing interest in the historyand development of the field of microbial symbiosis and its impact on biology; a focusedeffort in this area promises to drive an unprecedented integration across biology as awhole.

SPEAK ERSMarie-Claire Arrieta, PhDAssistant Professor University of CalgaryContribution of Gut Fungi to Gut Microbiome Ecology and Early-LifeImmune DevelopmentDr. Marie-Claire Arrieta is an Assistant Professor in thedepartments of Physiology, Pharmacology and Pediatricsof the University of Calgary. Her research examines theinteractions between the early-life gut microbiome andthe infant’s immune system. Her research programis framed around a translational approach, in whichsamples collected from children undergoing clinicalcare or enrolled in a birth cohort studies are used tocharacterize the microbial alterations (dysbiosis) associatedwith asthma and asthma risk. Her research group alsoexamines the causality and mechanistic underpinnings of theseassociations in well-established mouse models of allergic airway inflammation, placingher work at the interface between clinical studies and experimental animal work.As an advocate of science communication to the public, Dr. Arrieta has written a bestselling public book, Let Them Eat Dirt, and is involved in several science communicationinitiatives within Canada and abroad, including public talks, a second book and adocumentary film project.Meghan Azad, PhDAssistant Professor University of ManitobaMilk & Microbes: How Breastfeeding Shapes the Infant Microbiome andLifelong HealthDr. Meghan Azad is an Assistant Professor of Pediatrics and Child Health at the Universityof Manitoba. She holds a Canada Research Chair in Developmental Origins of ChronicDisease and co-Directs the new Manitoba Interdisciplinary Lactation Centre (MILC). Herresearch program (www.azadlab.ca) is focused on the role of infantnutrition and gut microbiota in the development of asthma,allergies and obesity. Dr. Azad co-leads the Manitobasite of the CHILD Cohort Study (www.childstudy.ca), anational pregnancy cohort following 3500 children tounderstand how early life experiences shape lifelonghealth. She directs multiple projects related to infantfeeding practices, human milk composition and themicrobiome in the CHILD cohort and other populations,including preterm neonates receiving donor milk, andBangladeshi infants at risk of malnutrition. Dr. Azad also leadscollaborative projects examining perceptions of breastfeedingon social media, and developing methods to improve societal support forbreastfeeding through school-based education programs.

SPEAK ERSYasmine Belkaid, PhDDistinguished Investigator NIHThe Adjuvant WithinDr. Yasmine Belkaid obtained her PhD in 1996 from the Pasteur Institute in France oninnate responses to Leishmania infection. Following a postdoctoralfellowship at NIAID on immune regulation during Leishmaniainfection, she joined the Children’s Hospital ResearchFoundation in Cincinnati as an assistant professor in 2002.In 2005, she joined the Laboratory of Parasitic Diseases asa tenure-track investigator. Since 2008, she has workedas an adjunct professor at the University of Pennsylvania.Martin Blaser, MDDirector Center for Advanced Biotechnology and MedicineConsequences from Perturbing the Early-Life Gut MicrobiotaMartin J. Blaser holds the Henry Rutgers Chair of the Human Microbiome at RutgersUniversity, where he also serves as Professor of Medicine and Microbiology, and as Directorof the Center for Advanced Biotechnology and Medicine. Previously, he served as Chairof the Department of Medicine at New York University. A physician and microbiologist,Dr. Blaser has been studying the relationships we have with our persistently colonizingbacteria. His work over 30 years focused on Campylobacter species and Helicobacterpylori, which also are model systems for understanding the interactions of residentialbacteria with their hosts. Over the last 20 years, he has also been actively studying therelationship of the human microbiome with health and important diseases includingasthma, obesity, diabetes, and cancer. Dr. Blaser has served as the advisor to manystudents, post-doctoral fellows, and junior faculty, and as President of the InfectiousDiseases Society of America, Chair of the Board of ScientificCounselors of the National Cancer Institute, and Chair ofthe Advisory Board for Clinical Research of the NIH. Hecurrently serves as Chair of the Presidential AdvisoryCouncil for Combatting Antibiotic Resistant Bacteria(PACCARB). He was elected to the National Academyof Medicine and the American Academy for Arts andSciences. He holds 28 U.S. patents, and has authoredover 580 original articles. He wrote Missing Microbes, abook targeted to general audiences, now translated into 20languages.

SPEAK ERSMaria Gloria Dominguez-Bello, PhDProfessor Rutgers UniversityThe Microbiome in an Age of Anthropogenic PerturbationsMaria Gloria Dominguez-Bello received her PhD fromUniversity of Aberdeen, Scotland. She worked at theVenezuelan Institute of Scientific Research in Venezuela,University of Puerto Rico, New York University School ofMedicine, and is currently the Henry Rutgers Professorof Microbiome and Health at Rutgers University. She isfellow at the American Academy of microbiology, an atIDSA, belongs to the editorial board of several journals,and the Medal of Merit given by the Venezuelan Instituteof Scientific Research. She and has over 135 publications inscientific journals and book chapters, and her current lab focusis on uses multidisciplinary approaches to study impacts of modern practices on themicrobiome and strategies for restoration. She works on gradients of urbanization in SouthAmerica, through global synergistic collaborations with scientists in Chile, Venezuela,Bolivia, Peru, Brazil, Tanzania, Spain, Belgium, Hong Kong and the US.Pieter Dorrestein, PhDDirector Collaborative Mass Spectrometry Innovation Centerat University of California San DiegoConnecting the World’s Metabolomics Data to Understand the Functionof the MicrobiomeDr. Dorrestein is a Professor at the University of CaliforniaSan Diego. He is the Director of the Collaborative MassSpectrometry Innovation Center and a Co-Director,Institute for Metabolomics Medicine in the Skaggs Schoolof Pharmacy & Pharmaceutical Sciences, and Departmentof Pharmacology. Since his arrival at UCSD in 2006, Dr.Dorrestein has been pioneering the development of massspectrometry methods to study the chemical ecologicalcrosstalk between the population of microorganisms,including host interactions for agricultural, diagnostic andtherapeutic applications.

SPEAK ERSWilliam Fenical, PhDDistinguished Professor Scripps Institution of Oceanography& University of California San DiegoThe Marine MicrobiomeWilliam Fenical (Bill) received his PhD in synthetic organicchemistry, and then joined the Scripps Institution ofOceanography (SIO), UC-San Diego, in 1973. Bill iscurrently Distinguished Professor of Oceanographyand Pharmaceutical Science, and Founding Director ofSIO’s Center for Marine Biotechnology and Biomedicine.Bill’s research interests have focused on the field ofmarine natural products chemistry. For the past 25 years his interests have been to develop marine microbialresources for the utilization of marine microorganisms as asource for new drug discovery. His efforts have resulted in theadvancement of two drugs, currently in phase III human trials forthe treatment of glioblastoma brain and non-small cell lung cancers and the discovery ofseveral potent new antibiotics. Bill has co-authored more than 480 papers in this field andhas served on the advisory boards of 8 major journals.Naama Geva-Zatorsky, PhDAssistant Professor TechnionCommunicating Complexity: What Can Information Visualization Teachus About Microbiome ReportingNaama Geva-Zatorsky, Assistant Professor at the Technion, Faculty of Medicine. PhD,at the Weizmann Institute, Systems-Biology with Prof. Uri Alon, completed with honorsand received the JFK, Teva and Barenholz awards. Postdoctoral studies, at HarvardMedical School, Mentor- Prof. Dennis Kasper and Profs. Benoist and Mathis. During herpostdoc, in a collaborative effort, characterized the host response to 60 different gutbacteria. She also applied metabolic labeling to enable, for the first time, visualization ofanaerobic gut microbes, in real time, in association with the host.In her lab, she is applying Systems-Biology bolomics and bacteriophage biology to study themechanistic interactions of the gut microbiota withmammalian host physiology in health and disease.Geva-Zatorsky recently received the Alon and Horevfellowships, the UNESCO-L’Oreal award, HumanFrontiers, EMBO and Fulbright fellowships, the CIFARAzrieli Global Scholar award of the Humans & MicrobiomeProgram and the Jonshon&Johnson WiSTEM2D award.

SPEAK ERSJack Gilbert, PhDProfessor Scripps Institution of Oceanography &University of California San DiegoThe Microbiome of the Built Environment: A New Way of Looking at anOld ProblemProfessor Jack A Gilbert earned his PhD from Unilever andNottingham University, UK in 2002, and received hispostdoctoral training at Queens University, Canada. From2005-2010 he was a senior scientist at Plymouth MarineLaboratory, UK; and from 2010-2018 he was a Professorof Surgery and Director of The Microbiome Center atUniversity of Chicago and a group leader at ArgonneNational Laboratory. In 2019 he moved to University ofCalifornia San Diego, where he is a Professor in Pediatricsand the Scripps Institution of Oceanography. He also holdsthe Yeoh Ghim Seng Visiting Professorship in Surgery atthe National University of Singapore. Dr. Gilbert uses molecularanalysis to test fundamental hypotheses in microbial ecology. He cofounded the EarthMicrobiome Project and American Gut Project. He has authored more than 250 peerreviewed publications and book chapters on microbial ecology. He is the founding Editorin Chief of mSystems journal.Karen Guillemin, PhDPhilip H. Knight Chair & Professor University of OregonTeaming with Microbes: Lessons from the ZebrafishKaren Guillemin is the Philip H. Knight Chair and Professor in the Department of Biologyand the Institute of Molecular Biology at the University of Oregon. She is also the foundingdirector of the Microbial Ecology and Theory of Animals (META) Center for HostMicrobe Systems Biology, established in 2012. Guillemin receivedher bachelor’s degree in Biochemical Sciences from HarvardCollege and her PhD from the Department of Biochemistry atStanford University School of Medicine, where she workedwith Dr. Mark Krasnow studying organ development inthe model organism of the fruit fly. She continued herpostdoctoral training at Stanford in the Department ofMicrobiology and Immunology with Dr. Stanley Falkow.Since joining the faculty of the University of Oregon, shehas pioneered gnotobiotic models, including the zebrafish,to study host-microbe systems in animal development anddisease.

SPEAK ERSJo Handelsman, PhDAssistant Professor Wisconsin Institute for Discovery atUniversity of Wisconsin MadisonTHOR: A Model MicrobiomeDr. Jo Handelsman is the Director of the Wisconsin Institutefor Discovery at the University of Wisconsin-Madison, aVilas Research Professor, and Howard Hughes MedicalInstitute Professor. She previously served as a scienceadvisor to President Barack Obama as the AssociateDirector for Science at the White House Office of Scienceand Technology Policy (OSTP) where she served forthree years until January 2017, and was on the facultyat the University of Wisconsin and Yale University beforethat. She received her PhD at the University of WisconsinMadison in Molecular Biology and has since authored over 200scientific research publications, 30 editorials, and 29 essays. Shehas authored numerous articles about classroom methods and mentoring and she is coauthor of six books about teaching - Entering Mentoring and Scientific Teaching. She isresponsible for groundbreaking studies in microbial communication and work in the fieldof metagenomics. She is also widely recognized for her contributions to science educationand diversity in science. Notably, she received the Presidential Award for Excellence inScience, Mathematics, and Engineering Mentoring from President Obama in 2011, and in2012, Nature named her one of “ten people who mattered this year” for her research ongender bias in science.Julie Horvath, PhDLab Head & Research Associate Professor North Carolina Museum of Natural Sciences & NC Central UniversityComparative Skin Microbiome ResearchJulie Horvath is an Associate Research Professor at NorthCarolina Central University in the Department of Biologicaland Biomedical Sciences and is jointly appointed as theHead of the Genomics and Microbiology Research Labat the North Carolina Museum of Natural Sciences. Sheholds adjunct appointments at NC State University andDuke University, and serves as an Associate Director forthe Triangle Center for Evolutionary Medicine. Her researchuses both comparative and evolutionary approaches toexplore how daily habits and host genetics influence themicroorganisms living on skin, and how the microorganisms, inturn, influence health and disease. She investigates the skin microbiota in humans andnon-human primates and engages students and the public through her research.

SPEAK ERSElaine Hsiao, PhDAssistant Professor University of California Los AngelesHost-Microbiome Interactions During Early NeurodevelopmentElaine Hsiao is a scientist in the Department of IntegrativeBiology & Physiology, where she leads a laboratory studyingbasic mechanisms for interactions between the gutmicrobiome, brain and behavior. Research from the Hsiaolab has led to the development of microbiota-basedinterventions for treating gastrointestinal and behavioralsymptoms of autism, regulating intestinal motility bycontrolling serotonin biosynthesis, and mediating theanti-seizure effects of the ketoge

Pediatric Hospital Medicine at University of California San Diego 4:40 PM - 5:00 PM Human Skin Microbiome: Trans-Kingdom, Host-Immune Interactions Julia Segre, PhD Senior Investigator NIH/NHGRI 5:00 PM - 5:20 PM The Marine Microbiome William Fenical, PhD Distinguished Professor Scripps Institution of Oceanography & University of California .